FORMULATION, CHARACTERIZATION AND IN VITRO EVALUATION OF FLOATING MICROSPHERES OF MEBENDAZOLE AS A GASTRO RETENTIVE DOSAGE FORM

Formulation Development and in Vitro Evaluation of Gastro Retentive Floating Microspheres of Verapamil Hydrocloride

Floating drug delivery system is one of the novel drug delivery system. Floating drug delivery system have a bulk density less than gastric fluids and thus it remains buoyant in the stomach without affecting gastric emptying rate for a prolonged period of time. Verapamil HCL is calcium channel blocker drug with short elimination half-life 2.8-7.4 hours Floating microspheres of Verapamil HCL wer...

Formulation, optimization and evaluation of gastro-retentive floating microspheres of norfloxacin

The objective of the present study was to develop floating microsphere of norfloxacin in order to achieve an extended retention in the upper GIT which may enhance the absorption and improve the bioavailability. The microspheres were prepared by solvent evaporation method using different ratio of hydroxyl propyl methyl cellulose (HPMC K4M, HPMC K15M) and ethyl cellulose with drug in the mixture ...

Floating microspheres of cimetidine: formulation, characterization and in vitro evaluation.

The present study involves preparation and evaluation of floating microspheres with cimetidine as model drug for prolongation of gastric residence time. The microspheres were prepared by the solvent evaporation method using polymers hydroxypropylmethyl cellulose and ethyl cellulose. The shape and surface morphology of prepared microspheres were characterized by optical and scanning electron mic...

Cefpodoxime Proxetil Floating Microspheres: Formulation and In Vitro Evaluation

      The objective of the present study was to develop floating microspheres of cefpodoxime proxetil in order to achieve an extended retention in the upper GIT, which may result in enhanced absorption and thereby improved bioavailability. The microspheres were prepared by non-aqueous solvent evaporation method using polymers such as hydroxyl propyl methyl cellulose (HPMC K 15 M), ethyl cellulo...

Atenolol Gastro Retentive Floating Matrix Tablets: Formulation and In-Vitro Evaluation